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qRT-PCR analysis revealed the marked upregulation of CDKN2A (encoding p16) , CDKN1A (encoding p21) , interleukin-8 ( IL-8) , and matrix metalloproteinase ( MMP)-12 expression (Figure 1D)
Researchers believe this reduction may partly contribute to slower healing, collagen loss, inflammation, tissue degeneration, and visible signs of aging
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