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The disproportionate occurrence of GI AEs may have lead to unblinding and contributed bias to patient-reported outcomes such as HRQoL and safety outcomes

YourProtocol's position aligns with a growing body of work on oral peptide formulations, though researchers should be aware that oral bioavailability is typically lower than injectable routes

Samples from all 8 patients was used, except for thalidomide where patient 7 was excluded due to inadequate cell numbers