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Several active immunotherapy candidates show improved safety but mixed efficacy in slowing cognitive decline and reducing A plaque burden in phase 1/2 trials.75 The ACI-24 vaccine showed beneficial effects on A plaque load and microglial phenotypes in preclinical studies and was well tolerated in a randomized trial of young adults with Downs syndrome.7476 Additionally, the first human phase 1/2a study of autologous A mutant peptide-pulsed dendritic cells (ALZN002) is ongoing in participants with mild to moderate Alzheimers disease (NCT05834296)
doi:10.1177/03000605231177191 20
It never gained FDA approval in the U.S
Semaglutide in type 2 diabetes with chronic kidney disease at high risk progression-real-world clinical practice
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