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These effects appear to be mediated by central actions in the brain, not just peripheral effects on the gut
Its this fact that tirzepatide mimics two hormones instead of one that is the main difference between semaglutide and tirzepatide
Because tirzepatide activates two receptors (GLP-1 and GIP) while semaglutide activates one (GLP-1 only), the shape of this dose-response relationship may differ between the medications
Diabetologia 1995;38(1):123
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