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Recently, ACMSD inhibitors were investigated in the human liver organoid model of metabolic dysfunction-associated steatohepatitis (MASH), an advanced form of liver fibrosis characterized by mitochondrial dysfunction
In the phase 1/2 trial, alpelisib (a PI3K inhibitor) plus nab-paclitaxel was well tolerated and showed encouraging efficacy, especially in patients with metastatic PIK3CA -mutated HER2 breast cancer, despite that TNBC has lower efficacy than HR+/HER2 patients
D.BriggsM
In fact, we found that ABMR cells might have less antioxidant ability based on decreased glutathione metabolism
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