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Acknowledgements This study was in part funded by Ministry of University (MIUR) Progetti di Ricerca di Interesse Nazionale (PRIN) [2017FM74HK], EFSD Sanofi Programme 2022, SOPHIA Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875534, PON BIO-D ARS01_00876, MUR-PNRR M4C2I1.3 PE6 project PE00000019 Heal Italia (all to M.F.) Funding Open access funding provided by Universit degli Studi di Roma Tor Vergata within the CRUI-CARE Agreement