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The presence of skin hyperextensibility with velvety skin texture and the absence of atrophic scarring, as well as joint hypermobility and easy bruising, should raise suspicion of clEDS, caused by biallelic TNXB variants
En effet, une forte concentration en glutathion offre une rsistance aux molcules chimiothrapiques [13]
SLC7A5, a crucial amino acid transporter, likely contributes to ferroptosis susceptibility by altering intracellular amino acid pools, potentially impacting glutathione synthesis and, consequently, GPX4 activity
To elucidate the mechanism behind the beneficial effects of glutathione, further studies that examine the incorporation of orally administrated glutathione into the liver and the effects on the host redox system using stable isotope-labeled glutathione and animal models are required
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