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Induction of neurite outgrowth by alpha-phenyl-N-tert-butylnitrone through nitric oxide release and Ras-ERK pathway in PC12 cells
However, whilst multiple compounds targeting redox regulation have been reported to slow disease progression in SOD1 G93A mice (Dash et al., 2018), they have subsequently failed to enhance survival or improve motor function in ALS patients in clinical trials
Disruption of gut homeostasis, including alterations in gut microbiota composition, impaired intestinal barrier function and increased microbial translocation, initiates a cascade of immune activation and inflammatory responses that promotes advanced liver damage
Summary Keywords nitric oxide, viral infection, autophagy, redox signal, reactive oxygen species Citation Aquilano K, Baldelli S and Ciriolo MR (2014) Glutathione: new roles in redox signaling for an old antioxidant
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