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Studies have found that GLP-1R is widely distributed on pancreatic and other tissues and has multiple biological effects, such as reducing neuroinflammation, promoting nerve growth, improving heart function, suppressing appetite, delaying gastric emptying, regulating blood lipid metabolism and reducing fat deposition

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However, these studies excluded individuals with a history of major depression or psychiatric diseases and reported no significant differences in psychiatric outcomes between liraglutide and placebo groups

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