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Tirzepatide's greater glucose-lowering effect compared to semaglutide means hypoglycemia risk may increase, especially if you are also taking sulfonylureas or insulin
It may also play a role in reducing depression and anxiety, although further studies are needed to confirm these effects
Data from a 2026 study suggests that males taking tirzepatide are more likely to experience sleep issues than females
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
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