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While Vitamin B12 is a naturally occurring nutrient that is generally considered very safe even in high doses, it is still a medical treatment

Ageing Res Rev 67:101263

has been an advisory board member or consultant for Bristol Myers Squibb, Catalyst, Iovance, Jansen, Mallinckrodt, Merck, Mosaic ImmunoEngineering, Novartis, Oncosec, Pfizer, and Targovax and receives grant support from Bristol Myers Squibb and Incyte for work outside the scope of this article

Discussion Deficiency of vitamin D (VD) is a significant and most common risk factor for chronic diseases, including insulin resistance, obesity, diabetes, and atherosclerosis 20,21,22,23