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doi: 10.1016/j.cnp.2020.01.003 361 BrageBMichosADrumBFahlgrenMSzulkinRBertilsonBC

Retatrutide (LY3437943), marketed here as Reta-Solution, is an investigational multi-receptor peptide agonist that targets the receptors for GIP, GLP-1 and glucagon, and is used in experimental models of obesity, glycemic control and metabolic regulation

Compounds having logP oct 2.0 have optimal brain penetration

If you take insulin or sulfonylureas alongside your GLP-1 medication, discuss with your healthcare team whether these doses need adjustment as your eating patterns change, to avoid low blood glucose levels that can worsen fatigue