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HPLC Chromatogram of the standard mixture of the major components in Hitrechol (a) and Hitrechol capsules (b)

Overall agreement 55%: A+ 20%, A 35%, A 30%, D 0%, D 15%, D+ 0%

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In addition, the British National Formulary offers the following advice: Important: When prescribing an antipsychotic for administration on an emergency basis, the intramuscular dose should be lower than the corresponding oral dose (owing to absence of first-pass effect), particularly if the patient is very active (increased blood flow to muscle considerably increases the rate of absorption)