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PKF275-055, an analog of vildagliptin, is a novel, selective, orally bioavailable, and long-acting DPP-4 inhibitor that has shown promising benefits in the prevention, protection, and treatment of diabetic neuropathy
Additionally, CCL2, a neutrophil chemokine implicated in angiogenesis and the pathological changes of psoriatic lesions [24], was markedly elevated in psoriasis-induced mice
This does not eliminate TMAO production entirely, as some circulating levocarnitine can be excreted into the gut, but it likely reduces the total TMAO burden compared to equivalent oral doses
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