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The Jastreboff Phase 2 trial randomised 338 adults with body mass index 30 (or 27 with at least one weight-related condition) to retatrutide 1, 4, 8, or 12 mg subcutaneously once weekly, or placebo, for 48 weeks
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CPT1C is localized in the CNS, is a neuron-specific isoform, is expressed in the ER rather than the mitochondria, and has carnitine palmitoyltransferase activity [188]
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