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SGLT2 brain expression is lower compared to SGLT1, and it is localized mainly in the microvessels of the blood-brain barrier, in the amygdala, hypothalamus, periaqueductal gray, and in the dorsomedial medulla (Koepsell, 2020)

Can occasionally persist longer but may be reduced with strategies like dose adjustments or lifestyle modifications

The genetic test does not predict exact MIC B12 response or guarantee side-effect avoidance

This translated into real outcomes in the SELECT trial , where semaglutide reduced heart attacks, strokes and cardiovascular deaths by around 20% in people with established heart disease without diabetes