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The pivotal STEP trials for semaglutide and SURMOUNT trials for tirzepatide included thousands of participants with monitoring for suicidal ideation using standardized tools such as the Columbia-Suicide Severity Rating Scale (C-SSRS), and did not demonstrate elevated rates compared to placebo groups
Weight loss, particularly when accompanied by improved metabolic markers, has been associated with a reduced risk of these cancers
Realistic Expectations: Are They Safe
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