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To Raufman's surprise, in 1981 he discovered that when he put one of the peptides onto guinea pig pancreata, it caused a sharp rise in amylase, an enzyme made in the pancreas and salivary glands in the mouth to help the body break down carbohydrates (Raufman, Tensen, Sutliff
At 68 weeks, average weight loss was: In the 12mg group, 58.6% of participants lost at least 25% of their body weight and 39.4% lost at least 30%
A phase 2 trial published in the New England Journal of Medicine reported substantial average weight reduction in adults with obesity or overweight
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doi: 10.1002/smll.202309038 56 ODonoghueJFreemanF
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