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Glycine and proline, the dominant amino acids in collagen, appear to be particularly effective at stimulating these gut hormone responses

one five-day periodic fasting study reported elevated SIRT1 and SIRT3 expression as well as increased mitochondrial DNA in blood cells in healthy individuals, but did not link these changes to clinical endpoints such as reduced disease incidence or mortality [38, 39]

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These effects are usually mild and tend to get better as the body gets used to the medicine