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Retatrutide still looks like a strong efficacy story with a familiar GLP-1 class tolerability profile: nausea diarrhea constipation vomiting dose escalation friction That matters because the strongest drugs in obesity medicine usually ask the user to earn the result through titration discipline

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Moreover, it appears that it is the membrane-bound form of the enzyme, on sites such as the luminal surface of capillary endothelial cells, which is more important for GLP-1 degradation than the circulating (soluble) enzyme (74, 75), questioning the relevance of any association between the plasma activity per se and glycaemic control, since it is unclear whether changes in soluble DPP-4 activity in the circulation accurately reflect any changes in total DPP-4 activity