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First of all, they proved that DPP-4 activity was enhanced in the hippocampus of middle-aged mice, primarily in microglia, but treatment with Linagliptin reduced the activation of M1 Macrofage-type (pro-inflammatory) microglia and promoted M2 Macrofage-type (anti-inflammatory) polarization

As with all medications, especially those affecting complex systems like metabolism and cardiovascular function, further research is needed to fully understand the benefits and risks, including any effects on the heart muscle

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HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58, and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis