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Data availability Data underlying this manuscript are made accessible through the Virginia Tech Data Repository at References NIAAA
Irregular or missed periods Significant calorie restriction and rapid weight loss can disrupt the HPO axis, causing cycles to lengthen, shorten, or temporarily stop
Orforglipron weight loss results make it an effective oral GLP-1 weight loss option with the most flexible dosing of any medication in this class
They may conduct follow-up studies or change recommendations
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