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According to the Summary of Product Characteristics (SmPCs), dysgeusia (altered taste) is listed as an uncommon side effect (affecting fewer than 1 in 100 but more than 1 in 1,000 people) for oral semaglutide (Rybelsus)
GLP-1 medications work through two primary mechanisms within the brain: Strengthening the blood-brain barrier, which protects against harmful substances 28 Reducing neuroinflammation through specialized brain cells called microglia and astrocytes 29 GLP-1 receptor signaling enhances neuron growth and survival 28
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