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Treatment continuation should follow SmPC criteria, which generally require a minimum percentage weight loss within specified timeframes
It also worsens outcomes for newly diagnosed patients, and is linked to less favorable responses to disease-modifying therapies
L-carnitine-containing compounds demonstrate comparable hepatoprotective effects
Biologics modulation of lipid metabolism primarily operates through two fundamental mechanisms: (1) enhancing hepatic clearance of lipoproteins via upregulation of low-density lipoprotein receptor (LDLR) activity and (2) directly altering the composition, modification, and metabolism of atherogenic lipoproteins
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