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In fact, among over 14,500 participants across multiple studies assessing the risk of thyroid cancer incidence and the use of semaglutide (the active ingredient in GLP-1 agonists), the risk of thyroid cancer was less than 1%
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However, the potential reduction in healthcare resource use across both classes suggests a combination of both SGLT2is and oral GLP-1 RAs may confer long-term cost savings compared to SGLT2is and standard of care alone [32, 33]
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