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In research models, this inhibition indirectly preserves NAD by reducing methylation of nicotinamide, and also maintains SAM levels an effect precursors do not address
This is where some researchers deviate from the one-vial approach
These are laboratory observations in animals and are not evidence of any effect in humans
This method bypasses the digestive system, making it ideal for people who: Have trouble absorbing B12 due to gastrointestinal issues (like Crohns disease or coeliac disease) Are on medications that interfere with B12 absorption (like metformin or anti-acids) Follow vegan or vegetarian diets Have undergone gastric surgery
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