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In Vitro GLP-1R agonist 2 (100 nM, 1,000 nM) activates GLP-1 receptor-mediated cAMP production, with an EC 50 of 101 nM, but exhibits a self-limiting effect at high concentrations [2]
The relevant analytical framework follows the ICH Q6B guidance for peptide drug substances, which covers reporting of identity, purity, content, and impurity profiles
doi:10.1111/ene.13508 21SmithAG
The research is still early , but the mechanistic rationale is compelling
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