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For example, a non-randomized prospective observational study reported that a multi-component supplement containing vitamin D, folic acid, melatonin, and MI improved insulin resistance, androgen levels, and menstrual regularity over six months in women with PCOS (224)

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While clinical validation of this mechanistic advantage continues to evolve, the dual-inhibition profile positions Polmacoxib as a promising therapeutic option for managing osteoarthritis