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ViaCytes VC-02 product (phase 1/2, NCT03163511) demonstrated proof-of-concept for graft survival and C-peptide production in some patients, but inconsistent engraftment and fibrotic encapsulation have hampered insulin output [138]
Endocrinology 152: 3018-3029, 2011
Modern English references (Ashmarin 2010, Levitskaya 2004, Myasoedov 2017) provide bibliographic entry points to systematically deepen before designing a protocol, to avoid reinventing results already published 30 years ago in a less accessible language
It is real for a subset of users, and regulators have responded: the FDA added persistent sexual dysfunction to the label and, in 2022, agreed to list suicidal ideation as an adverse reaction
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