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In published in vitro and preclinical research, IGF-1 LR3 has been studied in connection with binding to the IGF-1 receptor (IGF-1R) and reduced affinity for IGF-binding proteins (IGFBPs), and with downstream signaling pathways including PI3K/Akt and MAPK/ERK
V., Zavarzina, N
This all said, these findings are consistent with recent literature on the potential benefit of GLP-1s for mental health
Reduced appetite & cravings (brain satiety centres)
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