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Tirzepatide works through several mechanisms: it slows gastric emptying, enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, and acts on central appetite-regulating pathways in the brain

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This perspective, supported by the Lancet Commission on Dementia Prevention, Intervention and Care, is grounded in large-scale observational studies linking factors such as low educational attainment, midlife hearing loss, hypertension, obesity, smoking, depression, diabetes, physical inactivity, and social isolation to increased dementia risk (103)