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Because Ozempic is not approved by the FDA for weight loss, weight management is considered an off-label use of Ozempic
Mechanistic sampling of intestinal tissue during this trial would best validate the reparative hypothesis if analyses include tight junction protein expression (e.g., claudins, occludin, zonula occludens-1), histologic healing assessments using validated indices (e.g., Geboes score, Robarts Histopathology Index), and intestinal permeability assays such as the lactulose-mannitol ratio
Weight regain is the norm, not the exception
10.1016/j.metabol.2019.04.014 17 HP.KK.HwR.HsB.RB.ZK.et al (2024)
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