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Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

While altered taste is reported more often, a complete loss of taste is uncommon

Creatine Creatine is a substance produced naturally in the body to help generate ATP in cells which is used as energy

All of these medications, however, are effective when paired with lifestyle modifications