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Furthermore, GIPR antagonism in combination with GLP-1R agonism synergistically reduced BW in DIO mice and obese cynomolgus monkeys 33 , suggesting the potential for a GIPR/GLP-1R bispecific molecule for improving the efficacy of obesity treatment

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doi: 10.1073/pnas.1821445116 28 DoddI

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Patients with RA should continue evidence-based DMARD therapy as recommended by the American College of Rheumatology, while any GLP-1 use should be reserved for approved indications such as diabetes or weight management under appropriate medical supervision

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