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Its important to follow this guideline rather than jumping ahead to the maximum dose, since that can come with pretty severe side effects, Vash says, including nausea, vomiting, and severe abdominal pain

While individual responses vary, there is a physiological basis for this: different sites have different rates of absorption, and slower absorption may reduce the intensity of GI side effects

The NLRP3 inflammasome pathway: A review of mechanisms and inhibitors for the treatment of inflammatory diseases