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Moreover, systems-level spectral imaging and PLAs reveals the spatial coupling among the ER, mitochondria, and LDs constitutes a tri-organelle architectures via ESYT-VAPB complexes (16), while factors such as MIGA2 and the VPS13D-ESCRT axis integrate spatial tethering with lipid transfer and membrane remodeling capabilities (95,96) to efficiently execute downstream metabolic programs
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Metformin targets mitochondrial glycerophosphate dehydrogenase to control rate of oxidative phosphorylation and growth of thyroid cancer in vitro and in vivo
Conducting comprehensive clinical research on cancer patients poses several challenges, but further studies in this direction are anticipated in the future (Chung and Park 2017
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