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Medical Considerations: Semaglutide or Tirzepatide, including micro-dose programs, cannot be prescribed and should not be purchased by individuals with a BMI under 25 (or under 20 for micro-dosing), an eating disorder, diabetes, gallbladder disease, history of drug or alcohol abuse, recent bariatric surgery, pancreatitis, medullary thyroid cancer or a family history of it, diabetic retinopathy, multiple endocrine neoplasia type 2, or those who are pregnant, breastfeeding, or planning to become pregnant

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In the SURPASS-CVOT trial, which compared it with another GLP-1 medication (dulaglutide) rather than a placebo, tirzepatide was non-inferior for major cardiovascular events and reduced the risk of death from any cause by 16%