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The GLP-1 conversation has accelerated this shift, bringing new attention to the importance of collagen, skin structure, and the role of professional treatments in maintaining a healthy, youthful appearance through lifes changes

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Melanocytes are bound to the basement membrane via collagen IV and laminin-mediated adhesion and to keratinocytes via E-cadherin and Desmoglein (see the Supplementary)

It is likely that, because of the very early loss of permanent dentition and the high likelihood of tumour recurrence, final rehabilitation of this infant's dentition will require a long-term, multidisciplinary approach involving costly interventions