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It binds to the growth hormone-releasing hormone receptor instead of the ghrelin receptor
It is one of the few peptides on this list with a genuine FDA approval behind it
The following information is provided for context only and reflects the inclusion criteria used in the 2023 Phase 2 clinical trial (Jastreboff et al., NEJM 2023) these are study-specific criteria and do not represent current UK prescribing standards or predict future NICE commissioning decisions
For some patients who benefit from gradual dose transitions , this inflexibility is a real limitation
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