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Serious Indicators of Vitamin B-12 Deficiency Severe vitamin B12 deficiency can cause signs and symptoms such as Yellow skin Weak muscles Numb or tingly hands or feet Trouble walking Severe joint pain Increasing shortness of breath Weight loss Irritability Lack of smell and taste sensations Memory loss Paranoia Delusions Deep depression What Does B12 Fatigue Feel Like

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The difference in efficacy between these two doses is modest, but the difference in side effects can be meaningful for some individuals

The pooled effect size was homogenous ( I 2 = 0%) (Fig