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In mouse models, GPER activation reduces inflammatory factor secretion and astrocyte activation following optic nerve injury by inhibiting nuclear factor kappa-light-chain enhancer of activated B cells (NF-B) signaling, protecting retinal neurons and alleviating neuroinflammation [71, 72]
PICOS (Patient, Intervention, Control, Outcome and Study type) criteria were used to screen and select studies
Current obstacles to successful local or systemic delivery of peptides include poor absorption, enzymatic degradation, and mucociliary clearance
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