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doi:10.1016/j.hermed.2015.03.001 494 KunnumakkaraABHarshaCBanikKVikkurthiRSailoBLBordoloiDet al

Dosing Phases, Titration & Cycling Unlike short recovery peptides, semaglutide is not run in on/off cycles. The documented protocol is a single continuous escalation to a maintenance dose that is then held, because the metabolic effect depends on sustained receptor engagement weight tends to return when the drug is stopped