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"People who have alcohol use disorder get an internal brain reward for drinking, and we think that the semaglutide removes at least part of that sense of being rewarded for taking a drink." Though the research is promising, Xu said it's merely an observational study from clinical trials, meaning more research is needed before her team makes any recommendations for prescribing semaglutide for substance use treatment
The needle is very thin (29-31 gauge), and subcutaneous tissue has fewer pain receptors than deeper layers, making the experience far less uncomfortable than many patients anticipate
Any trial off therapy should be clinician-guided with alternative supports in place, as medication pauses typically lead to weight regain without a comprehensive plan
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