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There are side effects, and they are not working when you stop using them

Adverse events leading to permanent discontinuation occurred in 6.9% of participants on semaglutide and 5.9% of those on placebo

Similarly, medical studies report that new GLP-1 prescriptions have become predominantly for obesity rather than diabetes: e.g., in 20192023 only ~57% of new GLP-1 patients had T2D (down from ~65% a decade earlier) ( [27] ) ( [28] )

Immediate medical attention is warranted if any of the following symptoms develop: Jaundice : yellowing of the skin or whites of the eyes, which may indicate significant liver dysfunction or bile duct obstruction Severe abdominal pain : particularly in the right upper quadrant or pain radiating to the back, which could suggest gallbladder problems, pancreatitis or other hepatobiliary complications Fever with abdominal pain : which may indicate cholecystitis (gallbladder inflammation) Dark urine accompanied by pale stools : suggesting impaired bile flow Unexplained bruising or bleeding : potentially indicating reduced synthesis of clotting factors by the liver For these symptoms, patients should contact NHS 111, seek same-day GP assessment, or attend A&E if symptoms are severe