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It should be noted that these findings do not imply that DPP-4 inhibitors are harmful in any way or that GLP-1 drugs are definitely beneficial for brain health.

Studies on -synuclein demonstrate that methionine residues near the N-terminus are more susceptible to copper-mediated oxidation than internal residues, with Met1 substitution decreasing Cu-peptide reduction potential by approximately 80 mV

Neuroprotection by the metabolic antioxidant -lipoic acid

Of note, ex vivo isolated islet experiments do not simulate the full range of regulation present in vivo under T2DM conditions [207], which requires further investigation to clarify