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This does not necessarily mean the medication is ineffective, as appetite suppression usually becomes stronger as the dose increases

This mechanism of action differs from that of sulfonylurea derivatives, which stimulate insulin release even at low blood glucose concentrations, which is fraught with the development of sulfonylurea-induced hypoglycemia not only in patients with type 2 diabetes mellitus, but also in healthy individuals

In bodybuilding, certain peptides, particularly growth hormone secretagogues (GHS), are used to stimulate the production of human growth hormone (HGH), which plays a large role in muscle development, recovery and fat metabolism

This reduces the risk of hypoglycaemia when used alone, though the risk increases when combined with sulfonylureas or insulin (which may require dose adjustments of these medications)