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Whereas the AP lies outside the bloodbrain barrier and has a high density of Gipr -expressing cells, most of which are GABAergic, many Gipr -expressing neurones in the hypothalamus have their cell bodies behind the bloodbrain barrier and include both glutamatergic and GABAergic neurons 16
N Engl J Med 387(10):882893
Gastrointestinal symptomsincluding nausea, vomiting, diarrhea, and constipationare frequent, particularly during dose escalation
Properties of four acute phase proteins: C-reactive protein, serum amyloid A protein, alpha 1-acid glycoprotein, and fibrinogen
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