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The compound has attracted scientific interest because of its interaction with nicotinamide N-methyltransferase (NNMT) , an enzyme involved in metabolic processes linked to cellular energy regulation and biochemical signaling pathways
a , Single-nucleus RNAseq (snRNAseq) of Gclc transcripts from the indicated cells present in human mammary tissue, from previously published data 72
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When SAMe is low, the remethylation of homocysteine to methionine is prioritized in the cell (instead of the transsulfuration pathway).[ref] Drains on methyl groups: About 40% of methyl groups are used for creatine synthesis, so when creatine levels are higher, it can reduce the need for methyl groups
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