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These findings are consistent with the results from the SURPASS-2 trial 7 , which demonstrated similar benefits of tirzepatide over semaglutide
In terms of side effects, most users report minimal issues, with occasional mentions of mild digestive discomfort
Summary Heart palpitations are relatively uncommon among semaglutide users, with one source reporting about 1% and broader summaries noting cardiovascular side effects under 5%, so most patients will not develop persistent arrhythmias
But it is most effective when it reaches and enters the blood stream
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