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Preliminary animal and small human studies suggest allulose may modestly stimulate GLP-1 secretion and reduce postprandial glucose
In summary, these nanoparticle platforms achieve multi-targeted intervention in mitochondrial dysfunction through environmentally responsive drug release and targeted delivery mechanisms, from ROS scavenging, membrane potential stabilization, ETC repair, to activation of the NAD+-Sirt1 axis and mitochondrial regeneration pathways, providing a new precision treatment model for RIRI therapy
Oral Pathol ., 24 , 102112
Further research, incorporating prospective designs, standardized discontinuations and detailed patient-reported outcomes with validated symptom severity assessment scores, could better elucidate the complex relationship between GLP-1RA use and specific side-effects across IBS subtypesincluding patients who discontinue therapy without switching
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